Tick references

  1. Keirans J, Durden L. Tick systematics and identification. In: Goodman J, Dennis D, Sonenshine D, editors. Tick-borne diseases of humans. Washington, DC: ASM Press; 2005. p. 401.
  2. Nijhof AM. A contribution to the development of anti-tick vaccines. PhD thesis Utrecht University, the Netherlands . 2010. 216 p.
    https://dspace.library.uu.nl/bitstream/1874/179135/2/nijhof.pdf
  3. Sonenshine D. Biology of ticks, vol 1. New York: Oxford University Press; 1991.
  4. Estrada-Peña A. Ticks as vectors: taxonomy, biology and ecology. Rev Sci Tech l’OIE [Internet]. 2015 [cited 2018 May 7];34(1):53–65. Available from:
    https://pdfs.semanticscholar.org/b274/937c8d9fa9ec80e3a88b8d419e699732311b.pdf
  5. Anderson JF, Magnarelli LA. Biology of Ticks. Infect Dis Clin North Am [Internet]. 2008 [cited 2018 Apr 16];22:195–215.
  6. Medlock JM, Hansford KM, Bormane A, Derdakova M, Estrada-peña A, George J, et al. Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe.
    https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-6-1
  7. Cull B, Pietzsch ME, Hansford KM, Gillingham EL, Medlock JM. Surveillance of British ticks: An overview of species records, host associations, and new records of Ixodes ricinus distribution. Ticks Tick Borne Dis [Internet]. 2018 [cited 2018 Apr 17];9(3):605–14.
  8. Paul REL, Cote M, Le Naour E, Bonnet SI. Environmental factors influencing tick densities over seven years in a French suburban forest.
    https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1591-5
  9. Pietzsch ME, Medlock JM, Jones L, Avenell D. Distribution of Ixodes ricinus in the British Isles : investigation of historical records. Med Vet Entomol. 2005;19:306–14.
    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2915.2005.00575.x
  10. James MC, Gilbert L, Bowman AS, Forbes KJ. The Heterogeneity, Distribution, and Environmental Associations of Borrelia burgdorferi Sensu Lato, the Agent of Lyme Borreliosis, in Scotland. Front Public Heal [Internet]. 2014;2(August):1–10. Available from:
    http://journal.frontiersin.org/article/10.3389/fpubh.2014.00129/abstract
  11. Hubálek Z, Halouzka J. Prevalence rates of Borrelia burgdorferi sensu lato in host-seeking Ixodes ricinus ticks in Europe. Parasitol Res [Internet]. 1998 [cited 2018 May 9];84(3):167–72. Available from:
    https://link.springer.com/content/pdf/10.1007%2Fs004360050378.pdf
  12. Wagemakers A, Staarink PJ, Sprong H, Hovius JWR. Borrelia miyamotoi: A widespread tick-borne relapsing fever spirochete [Internet]. Vol. 31, Trends in Parasitology. 2015 [cited 2018 May 21]. p. 260–9.
  13. Robertson JN, Gray JS, Stewart P. Tick bire and Lb risk at a recreational site in England.pdf. Eur J Epidemiol [Internet]. 2000 [cited 2018 Apr 13];16:647–52. Available from:
    https://link.springer.com/content/pdf/10.1023%2FA%3A1007615109273.pdf
  14. Abdullah S, Helps C, Tasker S, Newbury H, Wall R. Ticks infesting domestic dogs in the UK: a large-scale surveillance programme. Parasit Vectors [Internet]. 2016 Dec 7;9(1):391. Available from:
    http://dx.doi.org/10.1186/s13071-016-1673-4
  15. Tulloch JSP, Mcginley L, Sánchez-Vizcaíno, F, Medlock, J M, Radford, AD. The passive surveillance of ticks using companion animal electronic health records. Epidemiol. Infect. (2017), 145, 2020–2029. doi:10.1017/S0950268817000826
    https://www.ncbi.nlm.nih.gov/pubmed/28462753
  16. Ogden NH, Cripps P, Davison CC, Owen G. The ixodid tick species attaching to domestic dogs and cats in Great Britain and Ireland. 2000;332–8.
    https://www.ncbi.nlm.nih.gov/pubmed/11016442
  17. Gilbert L. Altitudinal patterns of tick and host abundance: A potential role for climate change in regulating tick-borne diseases? Oecologia. 2010;162(1):217–25.
    https://link.springer.com/article/10.1007/s00442-009-1430-x
  18. James MC, Bowman AS, Forbes KJ, Lewis F, McLeod JE, Gilbert L. Environmental determinants of Ixodes ricinus ticks and the incidence of Borrelia burgdorferi sensu lato, the agent of Lyme borreliosis, in Scotland. Parasitology [Internet]. 2012 [cited 2018 Apr 16];140(2):237–46. Available from:
    https://www.cambridge.org/core/journals/parasitology/article/environmental-determinants-of-ixodes-ricinus-ticks-and-the-incidence-of-borrelia-burgdorferi-sensu-lato-the-agent-of-lyme-borreliosis-in-scotland/6D7D9D7681E8DC3CA8D41C1BF3D7E893
  19. Kirby AD, Smith AA, Benton TG, Hudson PJ. Rising burden of immature sheep ticks (Ixodes ricinus) on red grouse (Lagopus lagopus scoticus) chicks in the Scottish uplands. Med Vet Entomol. 2004;18(1):67–70.
    https://doi.org/10.1111/j.0269-283X.2004.0479.x
  20. Millins C, Gilbert L, Johnson P, James M, Kilbride E, Birtles R, et al. Heterogeneity in the abundance and distribution of Ixodes ricinus and Borrelia burgdorferi (sensu lato) in Scotland: implications for risk prediction. Parasit Vectors [Internet]. 2016;9(1):595. Available from:
    http://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1875-9
  21. Ruiz-Fons F, Gilbert L. The role of deer as vehicles to move ticks, Ixodes ricinus, between contrasting habitats. Int J Parasitol [Internet]. 2010 Aug 1;40(9):1013–20. Available from:
    http://dx.doi.org/10.1016/j.ijpara.2010.02.006
  22. Matuschka FR, Richter D. Mosquitoes and soft ticks cannot transmit Lyme disease spirochetes [Internet]. Vol. 88, Parasitology Research. 2002 [cited 2018 May 16]. p. 283–4.
  23. Piesman J, Gern L. Lyme borreliosis in Europe and North America. Parasitology [Internet]. 2004 [cited 2018 May 16];129(7):S191–220.
  24. Gray JS. The ecology of ticks transmitting Lyme borreliosis [Internet]. Vol. 22, Experimental and Applied Acarology. 1998 [cited 2018 Apr 25]. p. 249–58.
  25. Lindgren E, Jaenson TGT. Lyme borreliosis in Europe: influences of climate and climate change, epidemiology, ecology and adaptation measures. World Heal Organ [Internet]. 2006 [cited 2018 Apr 13];35. Available from:
    http://www.euro.who.int/__data/assets/pdf_file/0006/96819/E89522.pdf
  26. Norman RA, Worton AJ, Gilbert L. Past and future perspectives on mathematical models of tick-borne pathogens. Parasitology [Internet]. 2015;143(7):850–9. Available from:
    http://www.journals.cambridge.org/abstract_S0031182015001523
  27. Perret J-L, Rais O, Gern L. Influence of Climate on the Proportion of Ixodes ricinus Nymphs and Adults Questing in a Tick Population. J Med Entomol [Internet]. 2004;41(3):361–5. Available from:
    http://jme.oxfordjournals.org/content/41/3/361.abstract
  28. Tomkins JL, Aungier J, Hazel W, Gilbert L. Towards an evolutionary understanding of questing behaviour in the tick Ixodes ricinus. PLoS One. 2014;9(10).
    https://doi.org/10.1371/journal.pone.0110028
  29. Lindgren E, Talleklint L, Polfeldt T. Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus. Environ Health Perspect. 2000;108(2):119
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637900/
  30. Randolph SE. Tick ecology: Processes and patterns behind the epidemiological risk posed by ixodid ticks as vectors [Internet]. Vol. 129, Parasitology. 2004 [cited 2018 Apr 25]. Available from:
    https://www.cambridge.org/core/journals/parasitology/article/tick-ecology-processes-and-patterns-behind-the-epidemiological-risk-posed-by-ixodid-ticks-as-vectors/CD1323D36AEEBEF1A35E0A311837F0FC
  31. Hancock PA, Brackley R, Palmer SCF. Modelling the effect of temperature variation on the seasonal dynamics of Ixodes ricinus tick populations. Int J Parasitol [Internet]. 2011 [cited 2018 Apr 25];41(5):513–22.
  32. Randolph et al. An empirical quantitative framework for the seasonal dynamics of Ixodes ricinus. Int J Paras [Internet]. 2002 [cited 2018 May 21];32:979–89.
  33. Gilbert L, Aungier J, Tomkins JL. Climate of origin affects tick (Ixodes ricinus) host-seeking behavior in response to temperature: Implications for resilience to climate change? Ecol Evol. 2014;4(7):1186–98.
    https://onlinelibrary.wiley.com/doi/full/10.1002/ece3.1014
  34. Estrada-Peña A. Distribution, Abundance, and Habitat Preferences of Ixodes ricinus (Acari: Ixodidae) in Northern Spain. J Med Entomol [Internet]. 2001 [cited 2018 Apr 25];38(3):361–70. Available from:
    http://www.bioone.org/doi/full/10.1603/0022-2585-38.3.361
  35. Lindström A, Jaenson TGT. Distribution of the Common Tick, Ixodes ricinus (Acari: Ixodidae), in Different Vegetation Types in Southern Sweden. J Med Entomol [Internet]. 2003 [cited 2018 Apr 25];40(4):375–8. Available from:
    https://doi.org/10.1603/0022-2585-40.4.375
  36. Tack W, Madder M, Baeten L, Vanhellemont M, Gruwez R, Verheyen K. Forest Ecology and Management Local habitat and landscape affect Ixodes ricinus tick abundances in forests on poor , sandy soils. For Ecol Manage [Internet]. 2012;265:30–6. Available from:
    http://dx.doi.org/10.1016/j.foreco.2011.10.028
  37. Millins C, Gilbert L, Medlock J, Hansford K, Thompson DB, Biek R. Effects of conservation management of landscapes and vertebrate communities on Lyme borreliosis risk in the United Kingdom. Philos Trans R Soc B Biol Sci [Internet]. 2017;372(1722):20160123. Available from:
    http://rstb.royalsocietypublishing.org/lookup/doi/10.1098/rstb.2016.0123
  38. Ogden NH, Nuttall PA, Randolph SE. Natural Lyme disease cycles maintained via sheep by cofeeding ticks. Parasitology [Internet]. 1997 [cited 2018 May 25];115(6):591–9.
  39. Oechslin CP, Heutschi D, Lenz N, Tischhauser W, Péter O, Rais O, et al. Prevalence of tick-borne pathogens in questing Ixodes ricinus ticks in urban and suburban areas of Switzerland. Parasites and Vectors [Internet]. 2017 [cited 2018 May 7];10(1). Available from:
    https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-017-2500-2
  40. Maetzel D, Maier WA, Kampen H. Borrelia burgdorferi infection prevalences in questing Ixodes ricinus ticks (Acari: Ixodidae) in urban and suburban Bonn, western Germany. Parasitol Res [Internet]. 2005 [cited 2018 May 7];95(1):5–12. Available from:
    https://link.springer.com/content/pdf/10.1007%2Fs00436-004-1240-3.pdf
  41. Pangrácová L, Derdáková M, Pekárik L, Hviščová I, Víchová B, Stanko M, et al. Ixodes ricinus abundance and its infection with the tick-borne pathogens in urban and suburban areas of Eastern Slovakia. Parasites and Vectors [Internet]. 2013;6(1):238. Available from:
    https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-6-238
  42. Jore S, Viljugrein H, Hofshagen M, Brun-Hansen H, Kristoffersen AB, Nygård K, et al. Multi-source analysis reveals latitudinal and altitudinal shifts in range of Ixodes ricinus at its northern distribution limit. Parasites and Vectors [Internet]. 2011 [cited 2018 May 2];4(1):84. Available from:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123645/pdf/1756-3305-4-84.pdf
  43. JPW Scharlemann, PJ Johnson, AA Smith DM and SR. Trends in ixodid tick abundance and distribution in Great Britain. Med Vet Entomol. 2008;22:238–47.
    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2915.2008.00734.x
  44. Materna J, Daniel M, Danielová V. Altitudinal distribution limit of the tick Ixodes ricinus shifted considerably towards higher altitudes in central Europe: results of three years monitoring in the Krkonose Mts. (Czech Republic). Cent Eur J Public Health [Internet]. 2005 Mar [cited 2018 May 2];13(1):24–8. Available from:
    http://www.ncbi.nlm.nih.gov/pubmed/15859176
  45. Per Moestrup Jensen, Hanna Hansen,. Spatial Risk Assessment for Lyme Borreliosis in Denmark. Scand J Infect Dis [Internet]. 2000;32(5):545–50. Available from:
    http://www.tandfonline.com/doi/full/10.1080/003655400458857
  46. Clutton-Brock, TH., Coulson, T., Milner J. Red deer stocks in the Highlands of Scotland. Nature [Internet]. 2004 [cited 2018 May 23];429(6989):11–2.
  47. Gilbert L, Maffey GL, Ramsay SL, Hester AJ. The effect of deer management on the abundance of Ixodes ricinus in Scotland. Ecol Appl. 2012;22(2):658–67.
    https://esajournals.onlinelibrary.wiley.com/doi/full/10.1890/11-0458.1
  48. Gilbert L. Can restoration of afforested peatland regulate pests and disease? J Appl Ecol. 2013;50(5):1226–33.
    https://besjournals.onlinelibrary.wiley.com/doi/full/10.1111/1365-2664.12141
  49. Ehrmann S, Liira J, Gärtner S, Hansen K, Brunet J, Cousins SAO, et al. Environmental drivers of Ixodes ricinus abundance in forest fragments of rural European landscapes. BMC Ecol [Internet]. 2017 [cited 2018 May 21];17. Available from:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586062/pdf/12898_2017_Article_141.pdf
  50. Cook MJ. Lyme borreliosis: A review of data on transmission time after tick attachment [Internet]. Vol. 8, International Journal of General Medicine. 2014 [cited 2018 May 7]. p. 1–8. Available from:
    http://www.dovepress.com/permissions.php
  51. Kahl O, Janetzki-Mittmann C, Gray JS, Jonas R, Stein J, de Boer R. Risk of Infection with Borrelia burgdorferi sense lato for a Host in Relation to the Duration of Nymphal Ixodes ricinus Feeding and the Method of Tick Removal. Zentralblatt für Bakteriol [Internet]. 1998 [cited 2018 May 7];287(1–2):41–52.
  52. Crippa M, Rais O, Gern L. Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticks. Vector-Borne Zoonotic Dis [Internet]. 2002 [cited 2018 May 23];2(1):3–9. Available from:
    https://doc.rero.ch/record/23139/files/Crippa_Mara_-_Investigations_on_the_Mode_20110531.pdf
  53. Piesman J, Mather TN, Sinsky RJ, Spielman A. Duration of tick attachment and Borrelia burgdorferi transmission. J Clin Microbiol [Internet]. 1987 [cited 2018 May 7];25(3):557–8. Available from:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC265989/pdf/jcm00087-0113.pdf
  54. Piesman J, Maupin GO, Campos EG, Happ CM. Duration of adult female Ixodes-dammini attachment and transmission of borrelia-burgdorferi, with description of a needle aspiration isolation method. J Infect Dis [Internet]. 1991 [cited 2018 May 7];163(4):895–7. Available from:
    https://academic.oup.com/jid/article-abstract/163/4/895/944622
  55. Estrada-Peña A, De La Fuente J, Ostfeld RS, Cabezas-Cruz A. Interactions between tick and transmitted pathogens evolved to minimise competition through nested and coherent networks. Sci Rep [Internet]. 2015 [cited 2018 May 25];5. Available from:
    https://www.nature.com/articles/srep10361.pdf
  56. Rosà R, Pugliese A, Norman R, Hudson PJ. Thresholds for disease persistence in models for tick-borne infections including non-viraemic transmission, extended feeding and tick aggregation. J Theor Biol [Internet]. 2003 [cited 2018 May 25];224(3):359–76.
  57. Gray JS, Kahl O, Janetzki C, Stein J. Studies on the ecology of Lyme disease in a deer forest in County Galway, Ireland. J Med Entomol [Internet]. 1992 Nov [cited 2018 May 25];29(6):915–20. Available from:
    http://www.ncbi.nlm.nih.gov/pubmed/1460628
  58. Mysterud A, Easterday W, Qviller L, Viljugrein H, Ytrehus B. Spatial and seasonal variation in the prevalence of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in questing Ixodes ricinus ticks in Norway. Parasit Vectors [Internet]. 2013 [cited 2018 May 25];6(1):187. Available from:
    http://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-6-187
  59. Randolph SE. Ticks are not insects: Consequences of contrasting vector biology for transmission potential [Internet]. Vol. 14, Parasitology Today. 1998 [cited 2018 May 23]. p. 186–92.
  60. Mejlon HA, Jaenson TGT. Questing behaviour of Ixodes ricinus ticks (Acari: Ixodidae). Exp Appl Acarol [Internet]. 1997 [cited 2018 May 8];21(12):747–54. Available from:
    https://link.springer.com/content/pdf/10.1023%2FA%3A1018421105231.pdf
  61. Zeman P. Objective assessment of risk maps of tick-borne encephalitis and Lyme borreliosis based on spatial patterns of located cases. Int J Epidemiol [Internet]. 1997 Oct 1 [cited 2018 May 25];26(5):1121–30. Available from:
    https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/26.5.1121
  62. Gray JS, Kahl O, Robertson JN, Daniel M, Estrada-Peña A, Gettinby G, et al. Lyme borreliosis habitat assessment. Zentralblatt fur Bakteriol [Internet]. 1998 [cited 2018 May 7];287(3):211–28.
  63. Oteo JA, Martínez de Artola V, Gómez-Cadiñanos R, Casas JM, Blanco JR, Rosel L. Evaluation of methods of tick removal in human ixodidiasis. Rev clínica española [Internet]. 1996 Sep [cited 2018 May 7];196(9):584–7. Available from:
    http://www.ncbi.nlm.nih.gov/pubmed/8966318
  64. Roupakias, S., Mitsakou, P., Al Nimer A. Tick removal. J PREV MED HYG [Internet]. 2011 [cited 2018 May 8];52:40–4. Available from:
    http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.658.8903&rep=rep1&type=pdf
  65. Dillon, R., O'Connell, S. and Wright, S. (2010) Lyme disease in the U.K.: clinical and laboratory features and response to treatment. Clinical medicine 10(5), 454-457.
    http://www.clinmed.rcpjournal.org/content/10/5/454.abstract
  66. National Institute for Health and Care Excellence (NICE), ( 2018a) Lyme disease Finding more information and resources
    https://www.nice.org.uk/guidance/ng95
  67. PHE (2018) ‘Be tick aware’ – Toolkit for raising awareness of the potential risk posed by ticks and tick-borne disease in England , PHE publications gateway number: 2017871
    https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/694157/PHE_Tick_Awareness_Toolkit.PDF
  68. Dubrey, S.W., Bhatia, A., Woodham, S., Rakowicz, W., 2014. Lyme disease in the United Kingdom. Postgraduate Medical Journal. doi:10.1136/postgradmedj-2012-131522
    http://pmj.bmj.com/content/90/1059/33.long
  69. O’Connell, S., 2010. Lyme Borreliosis and other Ixodid Tick-borne Diseases – A European Perspective.
    http://pmj.bmj.com/content/90/1059/33.long
  70. Forest Research (2017) . Briefing Note: Lyme Disease :
    https://www.forestry.gov.uk/pdf/FR_LymediseaseBriefingNote.pdf/$file/FR_LymediseaseBriefingNote.pdf
  71. Hytonen, J., Hartiala, P., Oksi, J. and Viljanen, M.K. (2008) Borreliosis: recent research, diagnosis, and management, Scandinavian Journal of Rheumatology 37(3), 161-172.
    https://www.tandfonline.com/doi/full/10.1080/03009740801978897
  72. Lyme Disease UK (2018)
    http://lymediseaseuk.com/2015/10/26/tick-removal/
  73. Lyme Disease Action (LDA), 2018,
    http://www.lymediseaseaction.org.uk/about-ticks/tick-removal/
  74. NHS Inform
    https://www.nhsinform.scot/illnesses-and-conditions/infections-and-poisoning/lyme-disease
  75. Douglas, J, 2016 “About Tick Insects and Lyme Disease”
    https://www.youtube.com/watch?v=oCuWVqWdWUE&feature=youtu.be
  76. PHE (2018) Tick Surveillance Scheme
    https://www.gov.uk/guidance/tick-surveillance-scheme#tick-surveillance-scheme
  77. (European Centre for Disease Prevention and Control (ECDC), ( 2018) Lyme borreliosis - Information for the public on Tick Borne Diseases.
    https://ecdc.europa.eu/sites/portal/files/media/en/healthtopics/emerging_and_vector-borne_diseases/tick_borne_diseases/public_health_measures/Documents/GeneralPublic_InfoSheet_LB_highres.pdf
  78. Stanek, G., Fingerle, V., Hunfeld, K. et al. (2011) Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clinical microbiology and infection17 (1), 69-79.
    https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)60916-2/fulltext
  79. PHE (2014) Lyme disease: diagnosis and treatment. Guidance Public Health England.
    https://www.gov.uk/government/publications/lyme-disease-diagnosis-and-treatment/lyme-disease-diagnosis-and-treatment
  80. British Infection Association (2011). The epidemiology, prevention, investigation and treatment of Lyme borreliosis in United Kingdom patients: a position statement by the British Infection Association. Journal of Infection 62(5), 329-338.
    https://www.aldf.com/pdf/BIA%202011statement%20on%20Lyme%20disease.pdf
  81. Bratton, R.L., Whiteside, J.W., Hovan, M.J., Engle, R.L., Edwards, F.D., 2008. Diagnosis and treatment of Lyme disease. Mayo Clinic proceedings. Mayo Clinic 83, 566–571. doi:10.4065/83.5.566
    https://www.mayoclinicproceedings.org/article/S0025-6196(11)60731-3/fulltext
  82. Tramont, E.C. (2005) Treponema pallidum (syphilis). In: Mandell, G.L., Douglas, D.R., Bennett, J.E. and Dolin, R. (Eds.) Mandell, Douglas and Bennett's principles and practice of infectious diseases. 6th edn. Philadelphia: Elsevier Churchill Livingstone.
    https://www.nice.org.uk/guidance/ng95/chapter/Finding-more-information-and-resources
  83. James L⁄ynd Alliance, UK Lyme Disease priority setting partnership, the top 10 research priorities 2013.
    http://www.jla.nihr.ac.uk/priority-setting-partnerships/lyme-disease/top-10-priorities